#6009 MUSCLE OXYGENATION AND MICROVASCULAR REACTIVITY ACROSS DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE: A NEAR-INFRARED SPECTROSCOPY STUDY

Abstract Background and Aims Previous studies in chronic kidney disease (CKD) showed that vascular dysfunction different circulatory beds is progressively deteriorating with CKD severity. This study evaluated muscle oxygenation microvascular reactivity at rest, during an occlusion-reperfusion maneuver, exercise patients pre-dialysis versus controls, as well between stages Method Continuous measurement of [tissue saturation index (TSI%)] via near-infrared-spectroscopy occlusion-reperfusion, a 3-min handgrip exercise(at 35% maximal-voluntary-contraction). Aortic pulse wave velocity (PWV) carotid intima-media thickness (cIMT) were also recorded. Results Resting did not differ among the groups (controls: 64.3±2.9 stage-2: 63.8±4.2stage-3a: 64.1±4.1 stage-3b: 62.3±3.3 stage-4: 62.7±4.3%; p = 0.6). During occlusion, no significant differences detected TSIocl magnitude- occlusion-slope. However, reperfusion, theTSImax hyperemic response significantly lower more advanced 11.2±3.7 8.3±4.6 stage-3: 7.8±5.5 7.3±4.4 7.2±3.3; 0.04). exercise, (TSIaverage-decline) was marginally than but stages. Conclusion Although observed rest reperfusion impaired deteriorated ability microvasculature to respond stimuli may be crucial component adverse profile contribute intolerance